Cushing’s
disease/syndrome is a rather rare condition that occurs from being exposed to
high levels of cortisol for a long period of time. Most commonly it is caused by use of
corticosteroid medications, such as Prednisone…or if your body just makes too
much cortisol. Although this condition
is rare, you or your loved one may experience it at some point in your life. Good news is…it’s treatable with medical
care.
The signs
and symptoms experienced from one person to the next and from women to men may
vary, however common symptoms include noticing progressive obesity and skin
changes, including:
·
Experiencing
weight gain and collection of fatty tissue, particularly around your midsection
and upper back, in your face (moon face), and between the shoulders (buffalo
hump).
·
Stretch
marks appearing on the abdomen, thighs, breasts and arms.
·
Thinning
skin that becomes more and more fragile and bruises easily.
·
Slow
healing of cuts and/or infections.
·
Development
of acne.
·
Women
may experience thicker or more visible body/facial hair (hirsutism).
·
Men
may experience decreased libido and/or erectile dysfunction.
Other
signs and symptoms of this condition include:
·
Fatigue,
muscle weakness
·
Depression,
anxiety and/or irritability
·
Loss
of emotional control
·
Difficulty
processing thoughts
·
New
onset or worsening of high blood pressure
·
Intolerance
to blood sugar that may lead to diabetes
·
Headache
·
Bone
loss that may lead to fractures occurring easier over time
As
mentioned above, Cushing’s syndrome is a result of excess levels of the hormone
cortisol in your body. Cortisol is a
hormone that is produced by your adrenal glands, which sit atop both
kidneys. Cortisol plays a number of
roles in your body including:
·
Regulation
of blood pressure and keeps your cardiovascular system functioning as it should.
·
Helping
your body respond to stress and regulating the way you metabolize proteins,
carbohydrates, and fats in your diet to energy that you can actually use.
If you or
your loved one has been prescribed a corticosteroid medication, such as
prednisone, to treat a condition (asthma, arthritis, or inflammatory bowel
disease) generally the doses required to treat those conditions will often be
higher than the natural amount of cortisol your body normally needs each day,
so the effects of excess cortisol will begin to occur. Therefore, if you’re taking a corticosteroid,
or even if you are not taking a corticosteroid medication and you begin to
experience any of the symptoms listed above, it may indicate that you are
suffering from Cushing’s disease/syndrome and you should not hesitate to see
your provider for an exam. If left
untreated, this condition could lead to more severe health problems, including:
·
Bone
loss that results in unusual bone fractures (rib fractures and fractures of the
bones in the feet).
·
High
blood pressure.
·
Diabetes.
·
Frequent
or unusual infections that are hard to get rid of.
·
Loss
of muscle mass and strength
Diagnosis
of Cushing’s syndrome can be difficult because other conditions may share the
same signs and symptoms. Your medical
provider will complete a thorough physical exam and also note whether or not
you have been taking a corticosteroid medication. Urine, blood and imaging exams may be
performed in order to better pinpoint what is exactly going on in your body to
make a definitive diagnosis to rule out any other condition. Once diagnosed your best treatment option
will be designed with the goal of lowering the levels of cortisol in your
bloodstream and will depend on what is causing you to have the excess cortisol
floating around. Treatment measures may
include anything from oral medications to surgical procedures, or both.
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